Publications and presentations

Articles 
A. Wagner, R. Zarecki, L. Reshef, C. Gochev, R. Sorek, U. Gophna, E. Ruppin. Computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious. Proceedings of the National Academy of Sciences (PNAS) 2013;  doi: 10.1073/pnas.1312361110.

Bruun T, Kittang BR, de Hoog BJ, Aardal S, Flaatten HK, Langeland N, Mylvaganam H, Vindenes HA, Skrede S. Necrotizing soft tissue infections caused by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis of groups C and G in western Norway. Clin Microbiol Infect. 2013; 19:E545-50. doi: 10.1111/1469-0691.12276. 

R. Zarecki, M. Oberhardt, L. Reshef, U. Gophna, E. Ruppin (2014). A novel nutritional predictor links microbial fastidiousness wth lowered ubiquity, growth rate and cooperativeness. PLoS Computational Biology 2014, 10: e1003726; doi:10.1371/journal.pcbi.1003726.

Johansson L, J Snäll, P Sendi, A Linnér, P Thulin, A Linder, C-J Treutiger, A Norrby-Teglund. 2014. HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes. Frontiers Cell Infect Microbiol. 2014. 4:4.

Mairpady Shambat S, A Haggar, F Vandenesch, G Lina, W van Wamel, G Arakere, M Svensson, A Norrby-Teglund. 2014. Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community associated S. aureus isolates. PLoS One 2014. 9:e106107.

Fiebig A, Loof TG, Babbar A, Itzek A, Koehorst JJ, Schaap PJ, Nitsche-Schmitz DP. Comparative genomics of Streptococcus pyogenes M1 isolates differing in virulence and propensity to cause systemic infection in mice. Int J Med Microbiol. 2015; 305:532-43.

S Mairpady Shambat, P Chen, AT Nguyen Hoang, H Bergsten, F Vandenesch, N Siemen
s, G Lina, IR Monk, TJ Foster, G Arakere, M Svensson, A Norrby-Teglund. Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology.  Dis Model Mech. 2015; 8: 1413–1425.

Uhlmann J, Rohde M, Siemens N, Kreikemeyer B, Bergman P, Johansson L, Norrby-Teglund A. LL-37 Triggers Formation of Streptococcus pyogenes Extracellular Vesicle-Like Structures with Immune Stimulatory Properties. J Innate Immun. 2016;8: 243-57.

Chella Krishnan K, Mukundan S, Alagarsamy J, Laturnus D, Kotb M. Host Genetic Variations and Sex Differences Potentiate Predisposition, Severity, and Outcomes of Group A Streptococcus-Mediated Necrotizing Soft Tissue Infections. Infect Immun. 2015; 84: 416-24.

Siemens N, Kittang BR, Chakrakodi B, Oppegaard O, Johansson L, Bruun T, Mylvaganam H; INFECT Study Group, Svensson M, Skrede S, Norrby-Teglund A. Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections. Sci Rep. 2015; 25;5:16945. doi: 10.1038/srep16945.

Saccenti E, Nieuwenhuijse D, Koehorst JJ, Martins dos Santos VA, Schaap PJ. Assessing the Metabolic Diversity of Streptococcus from a Protein Domain Point of View. PLoS One. 2015; doi: 10:e0137908. 

Suarez-Diez M, Saccenti E. Effects of Sample Size and Dimensionality on the Performance of Four Algorithms for Inference of Association Networks in Metabonomics. J Proteome Res. 2015; 14: 5119-30.

MA. Oberhardt, R Zarecki, S Gronow, E Lang, HP Klenk, U Gophna, E Ruppin. Harnessing the landscape of microbial culture media to predict new organism-media pairings. Nature Communications 2015. 6:8493.

E Saccenti , J Camacho. On the use of the observation-wise k-fold operation in PCA cross-validation. Journal of Chemometrics 2015; 29: 467-478.

E Saccenti, M Suarez-Diez, C Luchinat, C Santucci, LTenori. Probabilistic Networks of Blood Metabolites in Healthy Subjects As Indicators of Latent Cardiovascular Risk. Journal of Proteome Research 2015; 14: 1101-1111.

E Saccenti, J Camcho. Determining the number of components in principal component analysis: A comparsion of statistical cross validation and approximated methods. Chemometrics and Intelligent Laboratory Systems. 2015. 149:99-116. 

esse CJ van Dam, JJ Koehorst, PJ Schaap  VAP Martins dos Santos, M Suarez-Diez. RDF2Graph a tool to recover, understand and validate the ontology of an RDF resource. Journal of Biomedical Semantics 2015. 6: 39

MA. Oberhardt , R Zarecki , L Reshef , F Xia , M Duran-Frigola , R Schreiber , CS Henry, N Ben-Tal , DJ Dwyer , U Gophna , E Ruppin. Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5’-Phosphate Production in E. coli. PLoS Computational Biology 2016. 12: e1004705

S. Mairpady Shambat, N. Siemnes, I.R. Monk, D.B. Mohan, S. Mukundan, K.C. Krishnan, S. Prabhakara, J Snäll, A. Kearns, F. Vandenesch, M. Svensson, M. Kotb, B. Gopal, G Arakere, A Norrby-Teglund. A point mutation in AgrC determines cytotoxicity or colonizing properties associated with phenotypic variants of ST22 MRSA strains. Scientific Reports 2016; 6: 31360. 

Hansen MB, Rasmussen LS, Garred P, Bidstrup D, Madsen MB, Hyldegaard O. Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study. Crit Care. 2016; 20:40. doi: 10.1186/s13054-016-1210-z.

Hansen MB, Rasmussen LS, Svensson M, Chakrakodi B, Bruun T, Madsen MB, Perner A, Garred P, Hyldegaard O, Norrby-Teglund A; INFECT study group. Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study. Sci Rep. 2017; 8;7:42179. doi: 10.1038/srep42179.

Siemens N, Chakrakodi B, Shambat SM, Morgan M, Bergsten H, Hyldegaard O, Skrede S, Arnell P, Madsen MB, Johansson L; INFECT Study Group., Juarez J, Bosnjak L, Mörgelin M, Svensson M, Norrby-Teglund A. Biofilm in group A streptococcal necrotizing soft tissue infections. JCI Insight. 2016; 7;1:e87882.

JJ Koehorts, JCJ van Dam, R.G.A. van Heck, E. Saccenti, V.A.P. Martin dos Santos, M. Suarez-Diez, P. Schaap. Comparison of 432 Pseudomonas strains through integration of genomic, functional, metabolic and expression data. Scientific Reports 2016; doi: 10.1038/srep38699

E Saccenti, G Menichetti, V Ghini, D Remondini, L Tenori, C Luchinat.  Entropy-Based Network Representation of the Individual Metabolic Phenotype. Journal of Proteome Research 2016; 15: 3298-3307

E Saccenti, ME Timmermann. Approaches to Sample Size Determination for Multivariate Data : Applications to PCA and PLS-DA of Omics Data. Journal of Proteome Research 2016. 15: 2379-2393. 

Snäll J, Linnér A, Uhlmann J, Siemens N, Ibold H, Janos M, Linder A, Kreikemeyer B, Herwald H, Johansson L, Norrby-Teglund A. Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release. Sci Rep. 2016; 18;6:21288. doi: 10.1038/srep21288.

Chella Krishnan K, Mukundan S, Alagarsamy J, Hur J, Nookala S, Siemens N, Svensson M, Hyldegaard O, Norrby-Teglund A, Kotb M. Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse. PLoS Pathog. 2016; 11;12:e1005732. doi: 10.1371.

Uhlmann J, Siemens N, Kai-Larsen Y, Fiedler T, Bergman P, Johansson L, Norrby-Teglund A. Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation. J Infect Dis. 2016; 15;214:1876-1883.

Madsen MB, Hjortrup PB, Hansen MB, Lange T, Norrby-Teglund A, Hyldegaard O, Perner A. Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med. 2017. doi: 10.1007/s00134-017-4786-0.

O Oppegaard, H Mylvaganam, S Skrede, PC Lindemann, BR Kittang. Emergence of a Streptococcus dysgalatiae subspecies stG62647-lineage ssociated with severe clinical manifestations. Scientific Reports 2017; doi: 10.1038/s41598-017-08162-z

M. Suarez-Diez, J. Adam, J. Adamski, S.A. Chasapi, C. Luchinat, A. Peters, C Prehn, C Santucci, A. Spyridonidis, G.A Spyrouöias, L. Tenori, R. Wang-Sattler, E. Saccenti. Plasma and Serum Metabolite Association Networks: Comparability within and between Studies Using NMR and MS profiling. Journal of Proteome Research 2017; 16:2547-2559.

E Saccenti. Correlation Patterns in Experimental Data Are Affected by Normalization Procedures: Consequences for Data Analysis and Network Inference. Journal of Proteome Research 2017; 16: 619-634.

E. Saccenti, M.E. Timmerman. Considering Horn’s Parallel Anaysis froma Random Matrix Theory Point of View. Psychometrika 2017; 82: 186-209. 

J Camacho,  RA. Rodríguez-Gómez, E Saccenti. Group-Wise Principal Component Analysis for Exploratory Data Analysis. Journal of Computational and Graphical Statistics 2017; doi: 10.1080/10618600.2016.1265527

O. Oppegaard, H. Mylvaganam, S. Skrede, B.K. Kittang. Exploring the arthritogenicity of Streptococcus dysgalctiae subspecies equisimilis. BMC Micobiol 2018; doi: 10.1186/s12866-018-1160-5

E. Saccenti, A. K. Smilde, J. Camacho. Group-wise ANOVA simultaneous component analysis for designed omics experiments. Metabolomics 2018; doi: 10.1007/s11306-018-1369-1

JJ Koehorst , JCJ van Dam , E Saccenti , VA P Martins dos Santos , M Suarez-Diez , PJ Schaap. SAPP: functional genome annotation and analysis through a semantic framework using FAIR principles. Bioinformatics 2018; 34: 1401-1403

A. Rosato, L. Tenori, M. Casante, P.D. De Atauri Carulla, V.A.P. Martins dos Santos. From correlation to causation: analysis of metabolomics data using systems biology approaches. Metabolomics 2018; 14: 37-42

A Emwas , E Saccenti , X Gao , RT McKay , VAP Martins dos Santos , R Roy , DS Wishart.  Recommended strategies for spectral processing and post-processing of 1D 1H-NMR data of biofluids with a particular focus on urine. Metabolomics 2018; 14: 31-37

A. Vignoli, L. Tenori, C. Luchinat, E. Saccenti. Age and Sex Effects on Plasma Metabolite Association Networks in Healthy Subjects. Journal of Proteome Research 2018; 17: 97-107

J Camacho , E Saccenti.  Group-wise partial least square regression. Journal of Chemometrics 2018; 32:e2964

N. Zondervan, J. van Dam, P. Schaap, V.A.P Martins dos Santos, M Suarez-Diez.  Regulation of Three Virulence Startegies of Mycobacterium tuberculosis: A success Story. International Journal of Molecular Science 2018; doi: 10.3390/ijms19020347

Kittang BR, Pettersen VK, Oppegaard O, Skutlaberg DH, Dale H, Wiker HG, Skrede S. Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer. BMC Infect Dis. 2017; 15;17:147. 

Madsen MB, Skrede S, Bruun T, Arnell P, Rosén A, Nekludov M, Karlsson Y, Bergey F, Saccenti E, Martins Dos Santos VAP, Perner A, Norrby-Teglund A, Hyldegaard O. Necrotizing soft tissue infections - a multicentre, prospective observational study (INFECT): protocol and statistical analysis plan. Acta Anaesthesiol Scand. 2018; 62:272-279. 

Rosén A, Arnell P, Madsen MB, Nedrebø BG, Norrby-Teglund A, Hyldegaard O, Dos Santos VM, Bergey F, Saccenti E; INFECT Study Group, Skrede S. Diabetes and necrotizing soft tissue infections-A prospective observational cohort study: Statistical analysis plan. Acta Anaesthesiol Scand. 2018 Apr 19. doi: 10.1111/aas.13130. 

Madsen MB, Hjortrup PB, Hansen MB, Lange T, Norrby-Teglund A, Hyldegaard O, Perner A. Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med. 2017;43:1585-1593. 

Babbar A, Bruun T, Hyldegaard O, Nekludov M, Arnell P; INFECT Study Group, Pieper DH, Itzek A. Pivotal Role of Preexisting Pathogen-Specific Antibodies in the Development of Necrotizing Soft-Tissue Infections. J Infect Dis. 2018;218:44-52.

Hansen MB, Rasmussen LS, Garred P, Pilely K, Wahl AM, Perner A, Madsen MB, Hedegaard ER, Simonsen U, Hyldegaard O. Associations of Plasma Nitrite, L-Arginine and Asymmetric Dimethylarginine With Morbidity and Mortality in Patients With Necrotizing Soft Tissue Infections. Shock. 2018;49:667-674.

Abstracts:
N Siemens, L Johansson, B Chakrakodi, the INFECT study group, M Svensson, A Norrby-Teglund. Pathogenesis of necrotizing soft tissue infections: analyses at the local tissue site in patient biopsies and in a novel 3D skin model. ECCMID 10-13 May 2014, Barcelona, Spain (Abstract 0063)

K. Hohenwarter. Fast and Cost-Effective Pathogen Diagnosis on an Automated DNA/Protein Diagnostics Platform Based on Cylindrical Microarrays (hybcells). ECCMID 10-13 May 2014, Barcelona, Spain (Abstract #4793)

A Babbar, DP Nitsche-Schmitz, GS Chhatwal, A Itzek, 1 INFECT study group. Identification of pathogen traits and host immune responses affecting the outcome of necrotizing soft tissue infections. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina (Abstract#69)

A Norrby-Teglund, M Svensson, O Hyldegaard, F Lind, Y Karlsson, P Arnell, S Skrede, M Kotb, D Pieper, V Martins dos Santos, F Vandenesch, C Reschreiter, D Marsden, E Ruppin, INFECT study group. The INFECT-project: A systems medicine approach to advance our understanding of necrotizing soft tissue infection. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina (Abstract#124)

Svensson M., Siemens N., Juarez J., Bosnjak L., Johansson L., Norrby-Teglund A., INFECT study group. Modelling early events of Gram positive bacterial infection in an organotypic model of human skin. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina (Abstract#61)

Siemens N., Kittang B.R., Johansson L., Chakrakodi B.,1 Kai-Larsen Y., Oppegaard O.,
Bruun T., Skrede S., INFECT study group, Norrby-Teglund A. Pathogenic mechanisms of Streptococcus dysgalactiae subsp. equisimilis in severe soft tissue infections. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina

Kaufmann, I. Value of single and combined inflammatory and kidney-dependent parameters for prediction of prognosis in septic shock. American Society of Anesthesiologists Annual Meeting, Oct 24 - 28, 2015. San Diego

K. Hohenwarter.  Sensitive Molecular Identification of Pathogenes Causing Implant Tissue Infection (ITI). ECCMID, Amsterdam April 9-12, 2016 (Abstract EP0143)
Bösl, A. Comparison of traditional blood culture and Hyborg Dx in patients suspicious for sepsis. ECCMID, Amsterdam April 9-12, 2016 (Abstract EV0501)

E Rath, T Bruun, O Hyldegaard, M Bruun-Madsen, M Nekludov, P Arnell, Y Karlsson, A Itzek, A Norrby-Teglund, S Skrede, INFECT Study Group. Clinical features of necrotizing soft tissue infections caused by beta-hemolytic Group A, C and G streptococci:  analysis of the Scandinavian INFECT study cohort. 20th Lancefield International Symposium on Streptococci and Streptococcal Diseases 2017, Fiji 16-20 October 2017.

Other presentations:
A Norrby-Teglund.Necrotizing soft tissue infections. Mayo Clinic, 10-12 September 2014 Rochester, US
A Norrby-Teglund. Deeper than skin: Immunopathogenesis of necrotizing soft tissue infections. NSCMID 25-27 September 2014, Bergen, Norway

S Skrede. Clinical challenges in severe soft tissue infections. NSCMID 25-27 September 2014, Bergen, Norway
A Norrby-Teglund. Necrotizing soft tissue infections (NSTI): pathogenesis at the tissue site. Skejby Symposium Intensive Care 7 October 2014, Aarhus, Denmark 2014

A Norrby-Teglund. New insights of pathogen – host interactions and EU project - INFECT. SMI: Superbugs and Superdrugs, London 16-17 March 2016

O Hyldegaard. Hyperbaric oxygen treatment as an adjunctive treatment to infectious diseases and its synergistic effects. SMI: Superbugs and Superdrugs, London 16-17 March 2016

A Norrby-Teglund. Advances in necrotizing soft tissue infections: from pathophysiology to clinics. ECCMID, Amsterdam 9-12 April 2016. 

A Norrby-Teglund. The INFECT-project; a multicentre prospective study on necrotizing soft tissue infections: from clinics to pathogenesis to intervention. 20th Lancefield International Symposium on Streptococci and Streptococcal Diseases 2017, Fiji 16-20 October 2017.

Anna Norrby-Teglund. INFECT: a European collaborative project utilizing a systems medicine approach to advance understanding of the pathogenesis of necrotizing soft tissue infections. ECCMID, Madrid 21-24 April 2018