Publications and presentations

Articles

A. Wagner, R. Zarecki, L. Reshef, C. Gochev, R. Sorek, U. Gophna, E. Ruppin (2013). Computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious. Proceedings of the National Academy of Sciences (PNAS), www.pnas.org/cgi/doi/10.1073/pnas.1312361110.

Bruun T, Kittang BR, de Hoog BJ, Aardal S, Flaatten HK, Langeland N, Mylvaganam H, Vindenes HA, Skrede S. Necrotizing soft tissue infections caused by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis of groups C and G in western Norway. Clin Microbiol Infect. 2013;19(12):E545-50. doi: 10.1111/1469-0691.12276. Epub 2013 Jun 25.

R. Zarecki, M. Oberhardt, L. Reshef, U. Gophna, E. Ruppin (2014). A novel nutritional predictor links microbial fastidiousness wth lowered ubiquity, growth rate and cooperativeness. PLoS Computational Biology, 10(7), e1003726, doi:10.1371/journal.pcbi.1003726.

Johansson L, J Snäll, P Sendi, A Linnér, P Thulin, A Linder, C-J Treutiger, A Norrby-Teglund. 2014. HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes. Frontiers Cell Infect Microbiol. 4:4.

Mairpady Shambat S, A Haggar, F Vandenesch, G Lina, W van Wamel, G Arakere, M Svensson, A Norrby-Teglund. 2014. Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community associated S. aureus isolates. PLoS One. 9:e106107.

Siemens N, Kittang BR, Chakrakodi B, Oppegaard O, Johansson L, Bruun T, Mylvaganam H; INFECT Study Group, Svensson M, Skrede S, Norrby-Teglund A. Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections. Sci Rep. 2015; 25;5:16945. doi: 10.1038/srep16945.

Hansen MB, Rasmussen LS, Garred P, Bidstrup D, Madsen MB, Hyldegaard O. Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study. Crit Care. 2016; 20:40. doi: 10.1186/s13054-016-1210-z.

Hansen MB, Rasmussen LS, Svensson M, Chakrakodi B, Bruun T, Madsen MB, Perner A, Garred P, Hyldegaard O, Norrby-Teglund A; INFECT study group. Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study. Sci Rep. 2017; 8;7:42179. doi: 10.1038/srep42179.

Siemens N, Chakrakodi B, Shambat SM, Morgan M, Bergsten H, Hyldegaard O, Skrede S, Arnell P, Madsen MB, Johansson L; INFECT Study Group., Juarez J, Bosnjak L, Mörgelin M, Svensson M, Norrby-Teglund A. Biofilm in group A streptococcal necrotizing soft tissue infections. JCI Insight. 2016; 7;1(10):e87882.

Snäll J, Linnér A, Uhlmann J, Siemens N, Ibold H, Janos M, Linder A, Kreikemeyer B, Herwald H, Johansson L, Norrby-Teglund A. Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release. Sci Rep. 2016; 18;6:21288. doi: 10.1038/srep21288.

Chella Krishnan K, Mukundan S, Alagarsamy J, Hur J, Nookala S, Siemens N, Svensson M, Hyldegaard O, Norrby-Teglund A, Kotb M. Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse. PLoS Pathog. 2016; 11;12(7):e1005732. doi: 10.1371.

Uhlmann J, Siemens N, Kai-Larsen Y, Fiedler T, Bergman P, Johansson L, Norrby-Teglund A. Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation. J Infect Dis. 2016; 15;214(12):1876-1883.

Madsen MB, Hjortrup PB, Hansen MB, Lange T, Norrby-Teglund A, Hyldegaard O, Perner A. Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med. 2017. doi: 10.1007/s00134-017-4786-0.

Kittang BR, Pettersen VK, Oppegaard O, Skutlaberg DH, Dale H, Wiker HG, Skrede S. Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer. BMC Infect Dis. 2017; 15;17(1):147. doi: 10.1186/s12879-017-2262-7.

Abstracts:

N Siemens, L Johansson, B Chakrakodi, the INFECT study group, M Svensson, A Norrby-Teglund. Pathogenesis of necrotizing soft tissue infections: analyses at the local tissue site in patient biopsies and in a novel 3D skin model. ECCMID 10-13 May 2014, Barcelona, Spain (Abstract 0063)

A Babbar, DP Nitsche-Schmitz, GS Chhatwal, A Itzek, 1 INFECT study group.

Identification of pathogen traits and host immune responses affecting the outcome of necrotizing soft tissue infections. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina (Abstract#69)

A Norrby-Teglund, M Svensson, O Hyldegaard, F Lind, Y Karlsson, P Arnell, S Skrede, M Kotb, D Pieper, V Martins dos Santos, F Vandenesch, C Reschreiter, D Marsden, E Ruppin, INFECT study group. The INFECT-project: A systems medicine approach to advance our understanding of necrotizing soft tissue infection. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina (Abstract#124)

Svensson M., Siemens N., Juarez J., Bosnjak L., Johansson L., Norrby-Teglund A., INFECT study group. Modelling early events of Gram positive bacterial infection in an organotypic model of human skin. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina

(Abstract#61)

Siemens N., Kittang B.R., Johansson L., Chakrakodi B.,1 Kai-Larsen Y., Oppegaard O.,
Bruun T., Skrede S., INFECT study group, Norrby-Teglund A. Pathogenic mechanisms of Streptococcus dysgalactiae subsp. equisimilis in severe soft tissue infections. XIX Lancefield 9-12 November 2014, Buenos Aires, Argentina

Other presentations:

A Norrby-Teglund.Necrotizing soft tissue infections. Mayo Clinic, 10-12 September 2014 Rochester, US

A Norrby-Teglund. Deeper than skin: Immunopathogenesis of necrotizing soft tissue infections. NSCMID 25-27 September 2014, Bergen, Norway

S Skrede. Clinical challenges in severe soft tissue infections. NSCMID 25-27 September 2014, Bergen, Norway

A Norrby-Teglund. Necrotizing soft tissue infections (NSTI): pathogenesis at the tissue site. Skejby Symposium Intensive Care 7 October 2014, Aarhus, Denmark 2014

A Norrby-Teglund. New insights of pathogen – host interactions and EU project -

INFECT. SMI: Superbugs and Superdrugs, London 16-17 March 2016

O Hyldegaard. Hyperbaric oxygen treatment as an adjunctive treatment to

infectious diseases and its synergistic effects. SMI: Superbugs and Superdrugs, London 16-17 March 2016

A Norrby-Teglund. Advances in necrotizing soft tissue infections: from pathophysiology to clinics. ECCMID, Amsterdam 9-12 April 2016.