Work packages

The project builds on nine distinct, yet highly integrated, work packages (WPs). This includes seven scientific work packages (WPs 1-7) combined with one dissemination work package (WP8) and one management work package (WP9).
  • Work Package 1 - WP1

    Here a systems genetics approach is applied to elucidate the mechanism and interactive host response pathways involved in modulating susceptibility and severity of necrotizing soft tissue infections (NSTIs).

    WP1 Systems genetics studies approach in a murine model of NSTIs
    Over all this WP aims at utilizing an experimental murine model of necrotizing severe soft tissue infections (NSTIs).
    Professor Malak Kotb
    Leader for WP1
    Professor Malak Kotb
    Department of Basic Sciences, School of Medicine and Health Sciences
    mkotbster@gmail.com
    University of North Dakota
    Grand Forks, North Dakota, United States
  • Work Package 2 - WP2

    There is an urgent need for improved diagnosis and treatment, as well increased understanding of parameters influencing disease progression and clinical outcome of NSTIs. In WP2, INFECT aims to achieve this by providing access to patient samples collected by standardized procedures and that are linked to systematically registered clinical data sets.

    WP2 Clinical registry of NSTIs and associated isolate and biobank collection
    This WP consists of The Scandinavian study group of NSTIs (partners 2-6) and the overall aim is to use a prospective study of NSTI patients at the major referral centers in Denmark, Sweden and Norway to obtain clinical samples that will be linked to detailed clinical information.
    Anders Rosemar, MD, PhD
    Sahlgrenska University Hospital
    Anders Rosen, MD
    Sahlgrenska University Hospital
    Ole Hyldegaard, MD, PhD
    Leader for WP2
    Ole Hyldegaard, MD, PhD
    Deptartment of Anaesthesia, Head and Neck Surgery Centre
    Ole.Hyldegaard@rh.regionh.dk
    University Hospital-Rigshospitalet
    2100 Copenhagen, Denmark
    Erik C Jansen, MD, Dr. Med. Sci.
    Erik C Jansen, MD, Dr. Med. Sci.
    Anæstesi- og operationsklinikken
    Erik.Jansen@regionh.dk
    HovedOrtoCenteret Rigshospitalet
    2100 Copenhagen, Denmark
    Diana Isaksen
    Anæstesi- og operationsklinikken
    diana.isaksen@regionh.dk
    Rigshospitalet
    2100 Copenhagen, Denmark
    www.anop.rh.dk
    Team leader, partner 3
    Michael Nekludov, MD
    Karolinska University Hospital
    michael.nekludov@karolinska.se
    Per Arnell, MD
    Per Arnell, MD
    per.arnell@vgregion.se
    Sahlgrenska University Hospital
    Rondvägen 5, 416 50, Gothenburg, Sweden
    Hans Lycke, MD
    hans.lycke@vgregion.se
    Sahlgrenska University Hospital
    Rondvägen 5, 416 50, Gothenburg, Sweden
    Joakim Trogen
    joakim.trogen@vgregion.se
    Sahlgrenska University Hospital
    Rondvägen 5, 416 50, Gothenburg, Sweden
    Kerstin Ohlauson
    kerstin.ohlauson@vgregion.se
    Sahlgrenska University Hospital
    Rondvägen 5, 416 50, Gothenburg, Sweden
    Ylva Karlsson, MD
    ylva.karlsson@ltblekinge.se
    Blekinge County Council Hospital, Karlskrona
    S-37 185 Karlskrona, Sweden
    Dag Benoni, MD
    dag.benoni@ltblekinge.se
    Blekinge County Council Hospital, Karlskrona
    S-37 185 Karlskrona, Sweden
    Steinar Skrede, MD, PhD
    Steinar Skrede, MD, PhD
    steinar.skrede@helse-bergen.no
    Haukeland University Hospital, Bergen, Norway
    Trond Bruun, MD
    trond.bruun@helse-bergen.no
    Haukeland University Hospital, Bergen, Norway
  • Work Package 3 - WP3

    This work package focus on the comprehensive and in-depth analysis of virulence gene repertoire of NSTI-causing pathogens, predominantly S. pyogenes and S. aureus.

    WP3 Identification of host and pathogen traits affecting disease outcome
    The overall aim of this work package is to identify specific pathogen and host disease signatures by applying a systems biology approach to identify host and pathogen specific traits associated to clinical outcome.
    Professor Dietmar Pieper
    Leader of WP3
    Professor Dietmar Pieper
    Microbial Interactions and Processes
    dpi@helmholtz-hzi.de
    Helmholtz-Zentrum für Infektionsforschung GmbH
    Inhoffenstraße 7, 38124 Braunschweig, Germany
    Andreas Itzek, PhD
    Department of Medical Microbiology
    Andreas.Itzek@helmholtz-hzi.de
    Helmholtz-Zentrum fuer Infektionsforschung GmbH
    Inhoffenstraße 7, 38124 Braunschweig, Germany
    Professor Francois Vandenesch
    Immunity Infection & Vaccination
    Francois.vandenesch@univ-lyon1.fr
    Université Claude Bernard Lyon 1
    INSERM Unit 1111, site Laennec, rue G. Paradin, 690008 Lyon
  • Work Package 4 - WP4

    Effective coordination between the experimental, bioinformatics and modeling tasks is pivotal for the success of an interdisciplinary project and the outlined systems medicine approach. The multiple and heterogeneous data sets from WP1, 2, 3, 5 and 6 are aggregated in a dynamic, relational database.

    WP4 Systems modeling and integration
    In this WP our overall aim is to identify and unravel host and pathogen key molecular networks underlying NSTIS by including the corresponding ‘omics’ data and implement specialized bioinformatics and modeling tools.
    Professor Vítor Martins dos Santos
    Leader for WP4
    Professor Vítor Martins dos Santos
    Laboratory of Systems and Synthetic Biology
    vitor.martinsdossantos@wur.nl
    Wageningen University
    Box 8033, 6700 EJ Wageningen, The Netherlands
    Jesse Vandam, PhD
    Wageningen University
    jesse.vandam@wur.nl
    Jasper Koehorst, PhD
    Wageningen University
    jasper.koehorst@wur.nl
    Peter Schaap, PhD
    Wageningen University
    peter.schaap@wur.nl
    Professor Vítor Martins dos Santos
    Lifeglimmer
    vds@lifeglimmer.com
    Markelstrasse 38, Berlin 12163, Germany
    lifeglimmer.com
    Babette Regierer, CEO
    Lifeglimmer
    info@lifeglimmer.com
    Professor Eytan Ruppin
    Professor Eytan Ruppin
    Tel Aviv University
    ruppin@post.tau.ac.il
    Raphy Zarecki, PhD
    Tel Aviv University
    raphy.zarecki@gmail.com
  • Work Package 5 - WP5

    The highly heterogeneous NSTIs require an individualized analysis approach, as different pathogenic mechanisms are likely to be involved and consequently, different individualized therapeutic approaches are warranted. Such analyses require a customized approach in which each patient is linked to its own infecting isolate.

    WP5 Host-pathogen interactions at the tissue site of infection (NSTI tissue biopsies)
    Overall this WP aims to validate results obtained in WP1-4, and to identify mechanistic action of novel therapeutic strategies. This will be done by analyses of molecular host-microbe interactions at the local site of infection, i.e. in patient tissue biopsies.
    Professor Anna Norrby-Teglund
    Leader for WP5
    Professor Anna Norrby-Teglund
    Center for Infectious Medicine, Karolinska Institutet
    anna.norrby-teglund@ki.se
    Karolinska University Hospital
    Huddinge F59, S-141 86 Stockholm
    ki.se/cim/norrby-englund_johansson
    Linda Johansson, PhD
    Linda Johansson, PhD
    Center for Infectious Medicine, Karolinska Institutet
    linda.johansson.2@ki.se
    Nikolai Siemens, Dr. rer. nat
    Center for Infectious Medicine, Karolinska Institutet
    nikolai.siemens@ki.se
  • Work Package 6 - WP6

    In NSTIs, different pathogenic mechanisms are likely to be involved causing cell death and widening of the intercellular spaces of basal cells and deeper tissues. Here, we explore mechanisms of pathogenesis and identify target molecules for novel therapeutic strategies using our unique skin tissue model.

    WP6 Artificial tissue model
    In this WP the overall aim is to explore how host and bacterial derived components contribute to the pathogenesis at the local site of infection in NSTIs.
    Mattias Svensson, PhD
    Leader for WP6
    Mattias Svensson, PhD
    Center for Infectious Medicine, Karolinska Institutet
    mattias.svensson@ki.se
    Karolinska University Hospital
    Karolinska University Hospital, Huddinge F59, S-141 86 Stockholm
    ki.se/cim/svensson
    Nikolai Siemens, Dr. rer. nat
    Center for Infectious Medicine, Karolinska Institutet
    nikolai.siemens@ki.se
    Karolinska University Hospital
    Karolinska University Hospital, Huddinge F59, S-141 86 Stockholm
  • Work Package 7 - WP7

    As “time-to-result” is crucial to improve clinical outcome, diagnostic tests that deliver fast results and that are easy to use are essential. Cube Dx’s technology is based on multiplexed diagnostics tailor-made for clinical application.

    WP7 Translation of results into prototype for novel diagnostics
    The overall aim of this WP is the translation of obtained results (clinically relevant pathogens and pathogenic disease traits) into a clinical compliant diagnostics approach by applying compact sequencing (pathogen detection - DNA) and compact profiling (disease traits – antigens) – both multiplex diagnostic technologies.
    Cristoph Reschreiter, MSc, CEO
    Leader for WP7
    Cristoph Reschreiter, MSc, CEO
    Cube Dx
    reschreiter@cubedx.com
    Westbahnstrasse 55
    A 4300 St. Valentine, Austria
    cubedx.com
    Bernard Ronacher, CSO
    Bernard Ronacher, CSO
    Cube Dx
    ronacher@cubedx.com
  • Work Package 8 - WP8

    Dissemination is a major task of INFECT as the results will be translated into guidelines for classification and management of NSTI (WP2) and development of novel diagnostic tools (WP7), which will be of great benefit to the health care and to the patients.

    WP8 Dissemination and exploitation
    In this WP, the overall aim is to ensure an efficient dissemination and exploitation of knowledge generated in INFECT.
    Steinar Skrede, MD, PhD
    Leader for WP8
    Steinar Skrede, MD, PhD
    Division for Infectious Diseases
    steinar.skrede@helse-bergen.no
    Haukeland University Hospital
    Jonas Liesvei 65, 5021 Bergen, Norway
    Trond Bruun, MD
    Haukeland University Hospital
    trond.bruun@helse-bergen.no
    Bergen, Norway
    Doreen Marsden
    Doreen Marsden
    The Lee Spark NF Foundation
    infect@nfsuk.org.uk
    nfsuk.org.uk
  • Work Package 9 - WP9

    INFECT is composed of a team of multidisciplinary researchers, clinicians, SMEs and a patient organization, each with a unique expertise, technical platform and/or model systems that together have the means to successfully conduct the research proposed.

    WP9 Management and consortium coordination
    The overall aim of this WP that includes the project management activities are to provide efficient management and administration of the project, while fulfilling all legal and EC requirements.
    Professor Anna Norrby-Teglund
    Professor Anna Norrby-Teglund
    Center for Infectious Medicine, Karolinska Institutet
    Karolinska University Hospital
    Karolinska University Hospital, Huddinge F59, S-141 86 Stockholm
    ki.se/cim/norrby-englund_johansson
    Mattias Svensson
    Mattias Svensson
    Center for Infectious Medicine, Karolinska Institutet
    mattias.svensson@ki.se
    Karolinska University Hospital
    Karolinska University Hospital, Huddinge F59, S-141 86 Stockholm
    ki.se/cim/svensson
    Linda Johansson
    Linda Johansson
    Center for Infectious Medicine, Karolinska Institutet
    linda.johansson2@ki.se
    Pierre Bodin
    Center for Infectious Medicine, Karolinska Institutet
    Pierre.Bodin@ki.se